Menopause marks a significant transition in a woman’s life, ushering in a cascade of physiological changes that inevitably affect health. One key aspect of this transition is the potential for increased insulin resistance, leading to various metabolic complications. Recent findings presented by Tanya Li from Drexel University College of Medicine shed light on an unexpected benefit of hormone therapy meant to alleviate menopausal symptoms: the reduction of insulin resistance in postmenopausal women. This article delves into the implications of these findings and their importance for clinical practices concerning hormone therapy for menopause.
A systematic review and meta-analysis involving 23 randomized controlled trials revealed that hormone therapy significantly improved insulin resistance metrics in healthy postmenopausal women. The methodology utilized the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), a standard method that correlates fasting insulin and glucose levels to gauge insulin sensitivity. The results indicated a notable reduction in insulin resistance among those receiving hormone therapy, with a mean difference of -0.239 compared to placebo groups, signifying a statistically significant improvement (P
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