On Tuesday, the U.S. Food and Drug Administration (FDA) took a significant step in the fight against early high-risk breast cancer by approving ribociclib, commercially known as Kisqali. This groundbreaking decision allows the CDK4/6 inhibitor to be utilized in combination with endocrine therapy as an adjuvant treatment for individuals diagnosed with stages II and III
Health
The treatment landscape for muscle-invasive bladder cancer (MIBC) has undergone significant change with recent studies illustrating the efficacy of combining immune checkpoint inhibitors, specifically durvalumab (Imfinzi), with neoadjuvant chemotherapy. The latest findings from the NIAGARA phase III trial have provided compelling evidence that supports the integration of perioperative durvalumab in improving survival outcomes for patients
Squamous cell carcinoma of the anal canal (SCAC) represents a unique and often neglected subset of malignancies that has seen a troubling rise in incidence over the years. This increase is particularly notable due to the endemic nature of human papillomavirus (HPV) and the association with immunocompromised states, such as HIV. Standard treatment options, primarily
Menopause marks a significant transition in a woman’s life, ushering in a cascade of physiological changes that inevitably affect health. One key aspect of this transition is the potential for increased insulin resistance, leading to various metabolic complications. Recent findings presented by Tanya Li from Drexel University College of Medicine shed light on an unexpected
In recent times, various health issues have emerged, intertwining with political discourses and societal norms. This article delves into several pressing topics, including healthcare initiatives, public health crises, and their implications on demographics, particularly the elderly. As we navigate the complexities of these subjects, it becomes evident that understanding the nuances is crucial for effective
A recent phase III trial revealed that an inexpensive antidepressant, mirtazapine, proved to be no more effective than a placebo in alleviating severe and persistent breathlessness in patients with chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD). This study, led by Irene Higginson, BMBS, PhD, from Kings College London, found that after 56
The testimony presented at the House Energy & Commerce Oversight and Investigations Subcommittee hearing shed light on the deeply troubling and unresolved issues within the organ transplant system in the United States. Shocking revelations ranged from potentially deceased organ donors regaining consciousness and whispering for help to threats of being “cremated alive” by organ transplant
CAR T-cell therapy has emerged as a groundbreaking treatment modality for various cancers, showing promising results in clinical trials. However, recent concerns have been raised regarding the potential risk of developing second primary malignancies (SPM) associated with this therapy. A systematic literature review and meta-analysis aimed to address this issue and provide insights into the
Childhood obesity is a growing concern worldwide, with many children struggling to achieve significant and sustainable weight loss through lifestyle interventions alone. In a recent phase IIIa trial known as SCALE Kids, researchers explored the potential benefits of adding liraglutide (Saxenda) to lifestyle intervention in young children with obesity. By the end of the 56-week
In a recent analysis of two phase III trials exploring the efficacy of perioperative nivolumab (Opdivo) in treating non-small cell lung cancer (NSCLC), there was a notable reduction in the risk of disease recurrence or death in post-surgical patients. The study conducted by Patrick Forde, MD, of Johns Hopkins Medicine, highlighted a compelling 40% decrease